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Herbs & Supplements

Printable Version Ademetionine
Scientific Name: S-adenosyl methionine (SAM-e)
Other Names: AldoMet, S-adenosyl-L-methionine, SAM, Sammy

What side effects should I watch for?

Major Side Effects

Serotonin syndrome, a rare but potentially dangerous oversupply of serotonin in the body, may be caused by SAM-e. Uncontrolled serotonin syndrome may result in coma, seizures, and death. Less serious symptoms of serotonin syndrome include:

  • Confusion
  • Excitement
  • Fever
  • Hallucinations
  • Inability to coordinate muscles
  • Restlessness
  • Shakiness
  • Vomiting

Less Severe Side Effects

Generally, most side effects associated with taking SAM-e have been mild and temporary. They include:

  • Anxiety
  • Constipation
  • Diarrhea
  • Dizziness
  • Dry mouth
  • Frequent urination
  • Headache
  • Insomnia
  • Nausea
  • Sweating
  • Thirst

Injectable SAM-e may be associated with the same side effects as oral SAM-e and it may also cause reactions such as itching or redness at the places where it is injected.

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Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.

In general, herbal products are not subject to review or approval by the U.S. Food and Drug Administration (FDA). They are not required to be standardized, meaning that the amounts of active ingredients or contaminants they contain may vary between brands or between different batches of the same brand. Not all of the risks, side effects, or interactions associated with the use of herbal products are known because few reliable studies of their use in humans have been done.

This information is provided for your education only. Please share this information with your healthcare provider and be sure that you talk to your doctor and pharmacist about all the prescription and non-prescription medicines you take before you begin to use any herbal product.

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